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pentobarbital will decrease the extent or impact of netupitant/palonosetron by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Netupitant is principally metabolized by CYP3A4; stay away from use in sufferers who will be chronically using a robust CYP3A4 inducerWarning is warranted for individuals with re